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COST Action BM0902

about COST Action BM0902

COST Chair


Laboratoire d'Hématologie
Institut de Biologie
Institut de Recherche Thérapeutique
8-9 Quai Moncousu
44007 Nantes Cedex 1, France

Supported by

about Cost

about European Science Foundation

Sponsored by

Univ. Montpellier 1          CHU Nîmes

Ligue contre le Cancer

Ipsogen             Roche Diagnostics

   SHIRE               Bristol Myers Squibb

COST Action BM 0902 is pleased to invite you to its

MPN&MPNr-EuroNet First Training School

Detection of mutations in MPN:
theory, practice (qPCR, HRM)

Nîmes, France - May 11-13, 2011

Organizer: Dr. Serge Carillo


The aims of MPN&MPNr-EuroNet's Training School to be held in Nîmes, France, May 11-13 2011 are the following:

  1. to acquire competences in the various techniques designed to detect the JAK2 and MPL mutations characteristic of Philadelphia-negative myeloproliferative neoplasms (MPN). The training school is organized in two sessions:
    • Morning plenary session/lectures: theory of the techniques.
    • Afternoon practical session: applicants will perform the different assays, assisted by experts.
  2. to get the latest information on the different mutations leading to MPN or to MPN transformation (GGCC/46.1 haplotype, TET2, CBP Alpha, CBL, ASXL-1, IDH-1, EZH, LNK...)
  3. to start a cooperative group which could share samples, reference materials and hopefully, generate original studies.

MPN&MPN-EuroNet offers five scholarships. To apply for a scholarship, applicant must send a mail to Mrs.Elodie Hervio explaining why she/he wishes to attend the training school and why a scholarship is needed. The applicant should also provide a short CV. Click on the following link to send a mail to Mrs. Elodie Hervio.

The deadline for application to a scholarship is March 30th, 2011.

Applicants will be informed of the decision regarding attribution of scholarship via e-mail by April 5th, 2011.


Applicants will acquire theoretical and practical competences enabling them to set up in their own laboratory the assays necessary for the detection and quantification of JAK2V617F, as well as assays for the detection of others mutations in the JAK2 and MPL genes.

The training school will deal with:

  • allelic burden quantification of the JAK2V617F mutation, using real time or LNA clamped PCR
  • HRM (High Resolution Melting analysis) detection of "second line mutations" of JAK2 and MPL: JAK2 exon12 mutations; mutations in other JAK2 exons; MPL exon10 mutations
  • Information and contacts with laboratories expert in the detection of rare mutations (TET2, CBP Alpha, CBL, ASXL-1, IDH-1, EZH, LNK ...).
Who is concerned ?

The maximum applicant number is 10 so that each trainee can practice in ideal conditions.

Applicants will benefit from the molecular biology platform of the University Hospital of Nîmes. They will practice under the guidance of experts. In order to maximize and facilitate exchanges, experts will be present with trainees for the whole day.

Deadline for application: Monday April 11th, 2011.

Registration fees : 250,00 €.


Molecular diagnostic, myeloproliferative neoplasms, JAK2 mutation, MPL mutation, allelic burden quantification

Join us in a friendly atmosphere and enjoy the training

Images : Office de Tourisme et des Congrès de Nîmes