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Molecular Analyses

  1. JAK2V617F
  2. JAK2 Exon 12
  3. MPL/TPO Receptor
  4. CALR
  5. Other MPN mutations
  6. EPO Receptor
  7. O2-sensing pathway genes
  8. THPO/Thrombopoietin

Mpl/TPO_Receptor

MPL encodes for the receptor for thrombopoietin. It has been found mutated in hereditary as well as acquired thrombocytosis. The mutations occur mainly in exon 10 of MPL, affecting S505 or W515.