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Molecular Analyses

  1. JAK2V617F
  2. JAK2 Exon 12
  3. Mpl/TPO_Receptor
  4. CALR
  5. Other MPN mutations
  6. EPO-Receptor
  7. O2-sensing pathway genes
  8. THPO

Mpl/TPO_Receptor

MPL encodes for the receptor for thrombopoietin. It has been found mutated in hereditary as well as acquired thrombocytosis. The mutations occur mainly in exon 10 of MPL, affecting S505 or W515.