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Laboratoire d'Hématologie
Institut de Biologie
CRCINA, Inserm U1232
Institut de Recherche en Santé 2 (IRS-2)
22 Boulevard Benoni Goullin
44200 Nantes

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Meeting Programme

Diagnostic of Sporadic and Hereditary
Myeloproliferative Diseases

WEDNESDAY April 25th, 2018

17:15 - 17:40 Registration
17:40 - 18:00 Welcome and Schedule
18:00 - 19:15 Diagnosis and significance of mutations in MPNs Chair: Aleksander B. Skotnicki (PL)
18:00 - 18:25 Mutations and their clinical relevance in myeloproliferative neoplasms Grzegorz Helbig (PL)
18:25 - 18:50 Diagnostic and prognostic significance of molecular testing in myelofibrosis Tomasz Sacha (PL)
18:50 - 19:15 Diagnostic algorithm for Philadelphia negative myeloproliferative neoplasms Joanna Góra-Tybor (PL)
19:15 - 19:45 Corporate Symposium Chair: François Girodon (FR)
19:15 - 19:30 Trusted solutions and innovations in MPN mutation analysis (QIAGEN) Véronique Laloux (FR)
19:30 - 19:45 Droplet DigitalTM PCR for the investigation of point mutations and fusion genes of the MPN portfolio of diseases (BioRad) Adam Corner (UK)
20:00 Welcome Dinner

THURSDAY April 26th, 2018

08:30 - 10:30 MPN mutations (I): NGS detection, validation, and quantification Chair: Julia Asp (SE)
08:30 - 09:00 Mutational analyses in the era of next generation sequencing Katerina Machova Polakova (CZ)
09:00 - 09:30 Diagnostic work up of MPNs using next generation sequencing Manja Meggendorfer (DE)
09:30 - 09:50 Characterization of NGS QC using quality metrics Naomi Porret (CH)
09:50 - 10:10 JAK2 V617F detection and quantification by ddPCR Elisabeth Oppliger (CH)
10:10 - 10:25 A comparison of qPCR and ddPCR in quantitative evaluation of JAK2 V617F allele burden in patient with Ph negative MPNs Dorota Link-Lenczowska (PL)
10:30 - 11:00 Coffee/tea break
11:00 - 12:45 MPN mutations (II): NGS detection, validation, and quantification Chair: Elisabeth Oppliger (CH)
11:00 - 11:30 Employing NGS to describe the genomic landscape of triple-negative MPNs Tomasz Stokłosa (PL)
11:30 - 12:00 Mutations in diagnostic samples of PV analyzed by the TruSight Myeloid Sequencing panel Julia Asp (SE)
12:00 - 12:30 JAK2/CALR screening of the Danish background population Lasse Kjaer (DK)
12:30 - 12:45 Clinical relevance of JAK2V617F mutational load in patients with MPN from Republic of Macedonia (Single-center experience) Marija Popova-Labachevska (MK)
12:45 - 13:30 Lunch
13:30 - 14:00 Free Time for Networking and Poster Session
14:00 - 16:30 Hereditary Erythrocytosis & Thrombocytosis Chair: Mary Frances McMullin (UK)
14:00 - 14:45 Differential diagnoses of Congenital Polycythemias/Erythrocytoses and their Erythroid and Non-erythroid Phenotypes Josef Prchal (CZ/USA)
14:45 - 15:15 A Gain-of-Function Mutation in EPO causes Familial Erythrocytosis Jakub Zmajkovic (CH)
15:15 - 15:40 Interest of Next generation sequencing for the detection of Hereditary Erythrocytosis-associated mutations François Girodon (FR)
15:40 - 16:10 A comprehensive Next Generation Sequencing Gene Panel focused on Idiopathic Erythrocytosis Mark Catherwood (UK)
16:10 - 16:20 Erythrocytosis as the first symptom of the complex hypermanganesemia syndrome due to mutations in SLC30A10 encoding a human manganese transporter Holger Cario (DE)
16:20 - 16:30 Germline JAK2 L611S mutation in a child with thrombocytosis François Girodon (FR)
16:30 - 17:00 Coffee/tea break
17:00 - 18:00 NGS and HE Business Sessions in small groups and Networking
20:00 Gala Dinner

FRIDAY April 27th, 2018

09:00 - 11:15 Inflammation and immune response in MPNs Chairs: Dorota Link-Lenczowska (PL) and Magdalena Zawada (PL)
09:00 - 09:30 Inflammatory cytokines in MPNs: Potential biomarkers and drivers of disease progression Nina Friesgaard Øbro (UK)
09:30 - 10:00 Impact of HSP27 in myelofibrosis as a new regulator of the JAK2/STAT5 signaling Aurélie de Thonel (FR)
10:00 - 10:30 The TLR4 and RAGE receptors conversely regulate pro-inflammatory S100A8/9 inhibition of proliferation-linked signaling in MPNs Vladan Cokic (RS)
10:30 - 11:00 Immune response to glycolipidic antigens in MPNs and other chronic hematological diseases Sylvie Hermouet (FR)
11:00 - 11:30 Coffee/tea break
11:30 - 12:30 General business session Chairs: Sylvie Hermouet (FR) and François Girodon (FR)
14th MPN&MPNr-EuroNet meeting in Belgrade (Spring 2019) Vladan Cokic (RS)
MPN&MPNr-EuroNet Budget 2017-2018 Sylvie Hermouet (FR)
MPN&MPNr-EuroNet in 2019 and beyond
12:30 - 13:30 Lunch
13:30 Meeting Adjourn - Good bye