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MPN&MPNr-EuroNet



about MPN&MPNr-EuroNet


Chair

Dr. Sylvie HERMOUET

Laboratoire d'Hématologie
Institut de Biologie
CRCINA, Inserm U1232
Institut de Recherche en Santé 2 (IRS-2)
22 Boulevard Benoni Goullin
44200 Nantes
France


Local Organizer



Institute for Medical Research
University of Belgrade, Serbia



Serbian Academy of Medical Sciences

Sponsored by



QIAGEN




NOVARTIS


Meeting Programme

Pathogenesis, diagnosis and therapy
of myeloproliferative neoplasm

WEDNESDAY May 8th, 2019

 
17:00 - 17:30 Registration
17:30 - 17:40 Welcome and Schedule Sylvie Hermouet (FR)
Vladan Čokić (RS)
17:40 - 19:40 Special session: Pathogenesis and therapy of MPN Chair: François Girodon (FR)
17:40 - 18:25 Origin and clonal evolution of myeloproliferative neoplasms Radek Skoda (CH)
18:25 - 19:05 Biological Impact of Interferon on MPN Isabelle Plo (FR)
19:05 - 19:25 Impact of Interferon on the therapeutic approach of MPN François Girodon (FR)
19:25 - 19:40 Discussion
 
20:00 Welcome Dinner
 

THURSDAY May 9th, 2019

 
08:30 - 10:35 WG1/2 session: Detection, Validation
and Quantification of MPN mutations
Chair: Julia Asp (SE)
08:30 - 09:00 Clinical relevance of additional mutations in MPN in a Swedish cohort Julia Asp (SE)
09:00 - 09:30 NGS in routine setting Beatriz Bellosillo (ES)
09:30 - 10:00 Multiple variants defining the genetic predisposition
to BCR-ABL-negative myeloproliferative neoplasms
Adrian Trifa (RO)
10:00 - 10:05 Discussion
10:05 - 10:15 Elevated NFE2 activity predisposes to leukemic transformation by increasing reactive oxygen species and DNA damage Christoph Köllerer (DE)
10:15 - 10:25 Mutational profiling in triple-negative essential thrombocythaemia with targeted next-generation sequencing Mark Catherwood (UK)
10:25 - 10:35 Hydroxyurea inhibition of erythroid progenitor growth is mediated in part by nitric oxide synthase activation and formation of nitric oxide Tijana Subotički (RS)
 
10:35 - 11:05 Coffee/tea break
 
11:05 - 12:40 Special Session: New Advances in Treatment of MPNs Chair: Andrija Bogdanovic (RS)
11:05 - 11:35 Transplantation Algorithm for Myelofibrosis in 2019 Donal McLornan (UK)
11:35 - 12:05 Disease classification and personalised prognosis in MPNs Jyoti Nangalia (UK)
12:05 - 12:25 Current medical treatment of MPNs Andrija Bogdanovic (RS)
12:25 - 12:30 Discussion
12:30 - 12:40 TEMPI syndrome - case report Danijela Leković (RS)
 
12:40 - 14:15 Lunch and Free Time for Networking and Poster Session
 
14:15 - 16:15 WG3 session: Hereditary Erythrocytosis and Thrombocytosis Chair: Mary Frances McMullin (UK)
14:15 - 14:45 Diagnostic pathways in erythrocytosis Mary Frances McMullin (UK)
14:45 - 15:15 Molecular diagnosis of idiopathic erythrocytosis:
a French experience
François Girodon (FR)
15:15 - 15:45 Novel Insights on Molecular Characterization
of Congenital Erythrocytosis
Celeste Bento (PT)
15:45 - 16:00 Discussion
16:00 - 16:10 Familial erythrocytosis: diagnostic strategy and clinical practice in Slovenia Aleša Kristan (SL)
16:10 - 16:15 Haemoglobin content of red blood cells is different in polycythemia vera (PV) and idiopathic erythrocytosis (IE) Giacomo Biagetti (IT)
 
16:15 - 16:45 Coffee/tea break
 
16:45 - 18:10 Special Session: Technological Advances Chair: Vladan Čokić (RS)
16:45 - 17:25 CRISPR-based Gene Editing: Concepts & Applications & Functional Rescue of a Novel Mpl Mutant in Primary HSPCs using Gene Editing Cédric Cleyrat (USA)
17:25 - 17:55 Genetically-engineered myeloid cells to reprogram the tumor microenvironment: from bench to bedside Bernhard Gentner (IT)
17:55 - 18:05 Effect of JAK2V617F on cytokine production in CRISPR-enginereed UT-7 cells Sylvie Hermouet (FR)
18:05 - 18:10 Discussion
 
20:00 Gala Dinner
 

FRIDAY May 10th, 2019

 
09:00 - 12:00 Special Session: Inflammation in MPNs Chair: Sylvie Hermouet (FR)
09:00 - 09:15 Qiagen presentation, Title to be announced Massimo Cerfeda (IT)
09:15 - 10:00 Inflammation as a driver of clonal evolution
in myeloproliferative neoplasm
Angela G. Fleischman (USA)
10:00 - 10:30 Inflammation mediated development of fibrosis in MPN Vladan Čokić (RS)
10:30 - 10:35 Discussion
 
10:35 - 11:15 Coffee/tea break
 
11:15 - 11:45 HSP and inflammation cytokines in MPNs Sylvie Hermouet (FR)
11:45 - 11:55 IL-6 stimulation of pro-inflammatory S100A mediators is NF-κB supported in mononuclear cells of essential thrombocythemia Miloš Diklić (RS)
11:55 - 12:00 Clinicopathological implications of bone marrow myeloid-derived suppressor cells in myeloproliferative neoplasms Sunčica Bjelica (RS)
 
12:00 - 12:30 General business session Chair: Sylvie Hermouet (FR)
 
12:30 - 13:30 Lunch
 
13:30 - 15:00 Sightseeing of Belgrade
 
15:00 Meeting Adjourn - Good bye